CUSTOM OLIGOS Oligos for spatial biology — without the friction
What we do Intrinsic BioSciences makes it effortless to design, order, and receive spatial-ready oligos.
Transparent pricing, rapid turnaround, and chemistry built for spatial workflows — so you can move from concept to slide without delay
We remove the friction between you and your sequences.
Intrinsic was built for one purpose: to make spatial-grade oligos as simple to order as primers.
We combine expert chemistry , transparent online workflows, and rapid synthesis to give every lab instant access to high-quality, spatial-compatible oligos.
Fluorescent Readout Probes
Multi-labeled DNA probes with custom dye conjugations
Oligo-tagged Antibodies
For spatial proteomic imaging
Encoding Pools
In situ hybridization probe design and pooled synthesis
Broad Application Areas
Spatial Transcriptomics, Genomics, Cyclic multiplexed smFISH
Truly Custom Oligos
Partner with us to design complex oligonucleotide constructs with never-before-seen modifications
01.
Cyclic smFISH
Single molecule fluorescence in situ hybridization (smFISH) is a technique that uses multiple fluorescently labeled DNA probes to specifically bind and visualize individual RNA molecules within fixed cells, enabling precise quantification and spatial localization of gene expression at single-molecule and single-cell resolution
02.
DNApaint
DNA-PAINT is a super-resolution microscopy technique that utilizes transient binding events between short fluorescently labeled DNA strands (imager strands) and target-bound complementary docking strands to achieve high-precision, multiplexed imaging of cellular structures at nanoscale resolution by analyzing stochastic blinking signals
03.
Primary and Secondary Probes
In smFISH, secondary readout probes are fluorescently labeled oligonucleotides that bind to complementary sequences on primary probes hybridized to target RNA, enabling signal amplification, multiplexed detection, or sequential imaging cycles by transiently highlighting different RNA species
ABOUT US
Intrinsic Bio is proud to supply premium reagents for all spatial biology applications, from academic research to biopharmaceutical development and diagnostics.
Brett Cook
Founder and CEO
Dr. Brett Cook is the founder of Intrinsic Biosciences, a startup focused on supplying custom oligonucleotide reagents for spatial biology applications. Before his business venture, Brett led early product development and marketing efforts at Rebus Biosystems, culminating in the product launch of the Esper imaging system and corresponding multiplexed smFISH reagent kit. Prior to joining Rebus, Brett was a scientist at Biosearch Technologies where he developed new DNA products for therapeutic and diagnostic applications. At Biosearch, he optimized phosphoramidite DNA synthesis methods for hot-start PCR, electrochemical DNA biosensors, and aptamer-based therapeutics. Brett obtained his PhD in Biomolecular Science and Engineering from the University of California, Santa Barbara, and a B.S. in Molecular Biology from the University of Washington, Seattle. At UCSB, he earned a certificate from the Technology Management Program and a top place in the annual New Venture Competition with a cancer diagnostic startup.
Intrinsic Bio seeks to reveal the intrinsic characteristics of biology for the purpose of understanding and improving human disease.
Flexible Designs
• Single or multi-labels
• Terminal or internal labels
• Non-standard fluorescent dyes
• Oligo-tagged antibodies
High Quality Synthesis
• Tunable scale from nanomole to micromole
• 3’, 5’ and internal modifications – custom and complex modifications available
• Standard desalting and HPLC purification available
• Click Chemistry and custom conjugations
Research Services
• Research Assay Development services
• In-house Microscopy Services
• High Performance Liquid Chromatography
• OEM kitting
Why Intrinsic Biosciences?
Purpose-built for the spatial era
Spatial Expertise
Oligos engineered specifically for spatial assays — optimized for hybridization efficiency, stability, and signal clarity.
Transparent & Fast
Instant quotes, no minimums, and turnaround in days — not weeks.
Quality Without Complexity
Validated synthesis chemistry with full traceability, ready to plug into your spatial workflow.
Open & Accessible
No vendor lock-ins, no gated catalogs — just clean design freedom.
Fuel your research with premium oligonucleotides 